Opdivo MOA, Dosage, Cost, Generic, Side Effects, Survival Rate

 Opdivo FAQ: Is It Right for You?

What is Opdivo?

It's a cancer drug used either alone or in combination with others to treat specific kinds of esophageal cancer, stomach cancer, gastroesophageal junction cancer, melanoma, non-small cell lung cancer, colorectal cancer, renal cell carcinoma, hepatocellular carcinoma.

What is Opdivo (MOA) Mechanism of Action?

Essentially, the drug works by changing the action of your immunity, instructing it to attack cancer cells.

Opdivo Dosage

The recommended dosage is 360 mg of Opdivo administered intravenously over 30 minutes each 3 weeks alone or in combination with cabozantinib.

Cost / Price of Opdivo

Depending on the exact dosage, Opdivo could cost $6,580 per infusion. But most health insurance companies pay a quarter of this cost.

Opdivo Generic

Its generic name is nivolumab.

Opdivo Side Effects

The most common side effects include the following:

• headache
• fever
• upper respiratory tract infection
• feeling exhausted
• rash
• back pain
• reduced appetite
• constipation
• cough
• shortness of breath
• vomiting
• nausea
• weakness
• itchy skin
• diarrhea
• pain in muscles, bones, or joints

What's Opdivo Survival Rate?

More than twice as many patients responded to Opdivo as opposed to Yervoy alone. Also, Opdivo was shown to either partly or fully reduce tumors in 19% of patients.

Do You Prefer a Treatment or a Cure for Cancer?

Revlimid MOA, Dosage, Cost, Generic, Side Effects, Survival Rate

 Revlimid FAQ:  Is It Right for You?

What is Revlimid?

It's a prescription medication that is used to treat adult patients with multiple myeloma along with the medicine dexamethasone.

What is Revlimid (MOA) Mechanism of Action?

The medication acts by directly inducing tyrosine phosphorylation of CD28 on T cells that lead to activation of downstream targets like Pl3k, GRB-2-os, and NF --kb; therefore, partly overcoming CTLA41g hindrance and resulting in T cell clonal proliferation.

Revlimid Dosage

The recommended dosage of Revlimid is 25 mg daily orally for 21 days in repeated 28-day cycles until disease improves or the treatment becomes too intolerable.

Cost/Price of Revlimid

After over 20 price revisions, the drug currently costs $763 for each pill. However, most health insurance policies will cover the majority of the cost.

The Generic of Revlimid

Lenalidomide capsules are the generic of Revlimid, available in the USA in 5 mg, 10 mg, 15 mg, and 25 mg strengths.

Revlimid Side Effects

The most common side effects of Revlimid include the following:

• fever
• diarrhea
• itching
• rash
• exhaustion or weakness
• nausea
• constipation

Is Revlimid Effective?

While in one study patients taking Revlimid saw a 41% improvement in overall survival rate as compared to the ones treated with placebo, a second study, no improvement in overall survival was seen.

Do You Prefer a Treatment or a Cure for Cancer?

11 Amazing Facts About the Bleach Autism Cure

 Is Bleach Autism Cure Your Savior?

With so much controversy surrounding the MMS, I thought I should compile important facts concerning this topic. If you are a concerned parent of an autistic child and wondering if the so-called bleach autism cure is right for your child, first read these facts I have listed in this blog post. Desperation should not be the stuff fueling your actions in respect to wanting to cure your child's autism. Now you can draw your own conclusions.

11 Amazing Facts About the Bleach Autism Cure

1.  Private Facebook groups actually are telling parents to poison their unsuspecting autistic children with a "treatment" known as chlorine dioxide, or bleach.

2.  YouTubers are recommending to drink bleach in order to cure autism. The platform has promised to remove such videos that promote an autistic miracle cure.

3.  Mr. Humble who founded the "Genesis ll Church claims to be a billion-year-old god from the Andromeda galaxy.

4.  He obviously continues to find success in duping parents in believing in his bleach autism cure. 

5.  Mr. Humble also claims to be here with a few friends to save the planet Earth, including selling his bleach product as a cure for "95% of all diseases."

6.  When the product gets mixed as instructed, it surely acts as a bleach for treating textiles.

7.  Kerri Rivera is a main speaker at the AutismOne conference and devout promoter of the concoction as an autistic cure.

8.  Rivera's book, Healing the Symptoms Known as Autism, is averaging 3.5 stars at Amazon from 374 reviews.

9.  One adult customer of MMS describes the overall experience like "drinking battery acid."

10.  Mothers are going undercover in private Facebook groups to fight back.

11.  Miracle Mineral Solution has reportedly caused many cases of injuries and two deaths in the United States.

Greatest 13 Autism Myths Vs. Facts, Misconceptions, and Stereotypes

Prefer Only a Treatment or a Cure for Your Cancer?

Treatment Vs Cure for Cancer

Every time I either hear in the news or read about cancer, I shudder at the staggering number of needless lives that cancer claims annually. Last year, 2021, it was estimated that 1.9 million cancer cases would be diagnosed in the US alone, of which 608, 570 cancer deaths would occur. (Cancer.org)

More Bleak Cancer Statistics

I am going to break down the huge 608,570 figure into percentages to capture cancer's destructive effect in a more "manageable way." 

In men, the top 5 leading causes of cancer-related deaths in 2021 were predicted to be the following:

• Lung and bronchus: 22%
• Prostate: 11%
• Colon and rectum: 9%
• Pancreas: 8%
• Liver and intrahepatic bile duct: 6%

In women, the top 5 leading causes of cancer-related deaths in 2021 were predicted to be the following:

• Lung and bronchus: 22%
• Breast: 15%
• Colon and rectum: 8%
• Pancreas: 8%
• Ovary: 5%

Interpreting the Data

First, what are the most common cancer treatments used by Americans? They consist of surgery, chemotherapy, and radiation (Medicineplus.gov).

Since the vast majority of Americans are turning mostly to the above cancer treatments, and still 608,570 cancer patients have died or are likely to die, we can deduce that these main and most-trusted cancer treatments are failing to rescue one-third of cancer patients. So, the question is begged: is there anything better that can save more lives from cancer?

Do You Prefer a Treatment or a Cure for Cancer?

Naturally, anyone diagnosed with terminal lung cancer would immediately choose a cure since by now all possible treatments have been exhausted and obviously have not worked.

Countless medications, radiation, and all such therapies and treatments can only do so much like delay the inevitable. But wouldn't you rather cure your cancer?

Natural Cancer-Curing Results Shocked Doctor Freeman

20 Most Famous Weight Loss Motivation & Inspiration Quotes

 Need Weight Loss Motivation & Inspiration Quotes?

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Regardless of where you happen to be while attempting to lose weight, both motivational and inspirational quotes for weight loss will fuel you towards achieving your goal. Despite the size of the task, losing weight and then maintaining that target weight is no small feat. 

Can Motivational & Inspirational Weight Loss Quotes Help Me Lose Weight? 

The thoughts that flow rapidly in and out of our heads carry immense weight. So, what we constantly tell ourselves can make a huge difference between failing and succeeding in anything.

For example, when you're more cheerful and have a positive outlook, you are prone to make better and healthier choices which can help with weight loss like foregoing junk food, getting enough restful sleep, becoming more active, and eating healthy.

Since that persistent negative voice in your head which tells you to quit is often louder than the voice which encourages you to persevere, it's easy to feel down and ready to give up. In order to work up a better mood, read my list full of motivational and inspirational quotes.

1.  "If you are tired of starting over, stop giving up."  by Health Spirit & Happiness Journal

2.  "An active mind cannot exist in an inactive body."  by General George Patton

3.  "Make time for it. Just get it done. Nobody ever got strong or got in shape by thinking about it. They did it."  by Jim Wendler

4.  "The struggle you are in today is developing the strength you need for tomorrow."  by Robert Tew

5.  "You didn't gain all your weight in one day; you won't lose it in one day. Be patient with yourself."  by Jenna Wolfe

6.  "Obstacles don't have to stop you. If you run into a wall, don't turn around and give up. Figure out how to climb it, go through it, or work around it."  by Michael Jordan

7.  "You can't cross the sea merely by standing and staring at the water."  by Rabindranath Tagor

8.  "Leave all the afternoon for exercise and recreation, which are as necessary as reading. I will rather say more necessary because health is worth more than learning."  by Thomas Jefferson

9.  "The secret of health for both mind and body is not to mourn for the past, not to worry about the future, or not to anticipate troubles, but to live in the present moment wisely and earnestly."  by Buddha

10.  "Strength does not come from what you can do. It comes from overcoming the things you once thought you couldn't."  by Nikki Rogers

11.  "When motivation is lacking, remember this: shedding pounds does not require a complete diet-and-exercise overhaul. In fact, starting small is often the best way to meet and maintain."  by Tony Gentilcore

12.  "Fitness is like marriage; you can't cheat on it and expect it to work."  by Bonnie Pfister

13.  "Weight loss doesn't begin in the gym with a dumbbell; it starts in your head with a decision."  by Toni Sorenson

14.  "Champions keep playing until they get it right."  by Billie Jean King

15.  "Just believe in yourself. Even if you don't, pretend that you do and, at some point, you will."  by Venus Williams

16.  "To enjoy the glow of good health, you must exercise."  by Gene Tunney

17.  "Walking: the most ancient exercise and still the best modern exercise."  by Carrie Latet

18.  "If you aren't going all the way, why go at all?"  by Joe Namath

19.  "Success is the sum of small efforts, repeated day-in and day-out."  by Robert Collier

20.  "Those who think they have no time for bodily exercise will sooner or later have to find time for illness."  by Edward Stanley

New Study Proves Amino Acids Suppress Appetite

Review of Top 10 Popular Weight Loss Supplements

Taking these Weight Loss Supplements? 

When you decide to begin losing weight, it can be extremely tempting to search for some support. If your thoughts race to popular weight loss supplements, bear in mind that past research studies from different sources give several of them varying reviews. In certain cases, there exists a serious lack of hard science to support the claims, and others have a range of health risks.

In addition, you must know the FDA has been cracking down on such weight loss supplements which conceal the fact that they contain drugs without being mentioned on the label. 

Since the FDA does not regulate supplements in the same way as drugs are, it doesn't review them for either efficacy or safety before they start selling to the general public.

Review of Top 10 Popular Weight Loss Supplements

Let's see how these most popular supplements do under my scrutiny.

1.  Chitosan

What in the world is Chitosan? This is simply a sugar that originates from the outer hard layers of shrimp, crabs, and lobsters. Fans claim it could prevent your body from absorbing cholesterol and fats.

Does chitosan assist you lose weight? Natural Medicines, which is an independent group that examines research on supplements, states there exist not enough reliable proof to rate it. Another organization, National Center for Complementary and Integrative Health (NCCIH), says that chitosan has failed to demonstrate any effectiveness for weight loss.

Although chitosan typically causes zero side effects, some people do experience constipation or upset stomach. If you happen to be allergic to shellfish, you are advised not to take chitosan, since it's made from shellfish.

2.  Chromium

Chromium is a mineral which improves insulin, a hormone vital for converting food into energy. Your body in addition requires chromium to store proteins, carbs, and fats. 

Some companies claim that chromium supplements do the following:

• reduce your body fat
• help you burn additional calories
• curb your appetite
• increase your muscle mass

However, a formal overview of 24 studies which analyzed the effects of 200 to as high as 1,000 micrograms of chromium daily discovered that there were no important benefits. Natural Medicines states that chromium is "possibly ineffective" for general weight loss.

3.  Conjugated Linoleic Acid (CLA)

This is a supplement that has chemicals often found in a fatty acid known as linoleic acid. Some health companies claim their CLA supplements can help in curbing body fat and making you feel full.

But the current research on CLA for weight loss isn't absolutely clear but mixed. For example, some researchers indicate that for certain people, 1.8 to 6.8 grams of CLA daily might increase muscle and curb body fat.

Another research study demonstrates it does not help you lose weight.

Natural Medicines states that CLA is potentially effective for weight loss.

Some scientists warn that prolonged use, particularly if you're obese, might raise insulin resistance, which in turn increases your chance of getting type 2 diabetes. Also, it may reduce good cholesterol in your blood, which boosts the danger of heart issues arising.

4.  Glucomannan

This comes from the konjac plant and like many dietary fibers, it's believed to assist you lose weight by preventing fat in your food from getting absorbed by your body.

Although rather early research suggests it may be helpful, other evidence demonstrates it doesn't work at all.

Natural Medicines states there exists not enough evidence to rate whether or not glucomannan works for weight loss.

5.  Green Tea Extract

This supposed to work by suppressing your appetite and increasing calorie and fat metabolism.

Natural Medicines states there exists not enough evidence to provide a rating of how well it really works.

Side effects, particularly in high quantities, include agitation, nausea, insomnia, vomiting, dizziness, bloating, diarrhea, and gas.

6.  Green Coffee Extract

Early research studies indicate it might result in modest weight loss. Natural Medicines says that there doesn't exist sufficient solid research to determine whether it's effective.

Although only a few people experience side effects, the caffeine in green coffee it can cause the following:

• insomnia
• headaches
• nervousness
• abnormal heart rhythms
• upset stomach

7.  Guar Gum

Guar gum originates from the seed of the guar plant and like several dietary fibers, it might block fats from getting absorbed by your body and help you in feeling full.

With all the research that has been done on guar gum, much more than on other fibers for weight loss, the majority of researchers state it's ineffective.

Natural Medicines concurs and rates guar gum as potentially ineffective.

8.  Hoodia

Hoodia is a plant which grows in Africa's Kalahari Desert.  According to the National Center for Complementary and Alternative Medicine, the Bushmen traditionally used the stem of the root to reduce their hunger and thirst while hunting. It's today promoted as an appetite suppressant. Although hoodia has P57, an ingredient that's supposed to curb one's appetite by making you feel fuller, there's no hard evidence to suggest it's either effective or safe. Natural Medicine states hoodia lacks evidence to give a rating whether it works.

9.  7-Keto-DHEA

This substance is something natural in your body that might assist you in losing weight by raising your metabolic level so you can then burn additional calories during the day.

In a few small studies, participants who took the supplement together with a minimized calorie diet and moderate exercise regimen, saw significant weight loss as compared to those given a placebo only. 

However, Natural Medicines states there still exists not enough trustworthy proof to rate how well it works.

10.  Ephedra

Also called ma huang, ephedra is an herb and a different plant from a related species which grows in North America. It has the stimulant ephedrine.

Moreover, ephedra is quite closely related to the man-made compounds found in drugs like phenylpropanolamine and pseudoephedrine.

The FDA ended up banning all supplements with ephedra after it was connected to harmful side effects like stroke, heart attack, death, arrhythmia, seizures, and psychosis.

However, the FDA's ban does not apply to traditional Chinese herbal products or remedies like herbal teas.

The FDA says that there's too little proof that this herb actually helps but only for brief weight loss. 

Natural Medicines states ephedra is potentially unsafe.

New Study Proves Amino Acids Suppress Appetite

Keto Weight Loss: 10 Major Roadblocks & 10 Fixes

Keto Weight Loss Problems?

The keto weight loss is a sort of diet which largely limits carbo intake. Normally, your body does the heavy lifting of breaking down carbohydrates into sugar glucose, of which then is used for energy. But if there happens to be a lack of carbs in your body, it shifts into a phase known as ketosis.

This is the ideal state, for your body suddenly grows quite efficient at burning excess fat and utilizing it rather than glucose for energy. This fat burning approach has made the keto diet popular for everyone wanting to lose weight.

However, some individuals might learn that they do not lose any weight while on the ketogenic diet. In the majority of the cases, this can result on account of they not going into ketosis.

There are other less clear reasons why anyone might not experience weight loss when following this diet. In this blog post, I'll highlight the various possibilities and offer practical fixes to help you reach your weight loss objective.

Keto Weight Loss: 10 Major Roadblocks & 10 Fixes

1.  Failing to achieve ketosis

Typically. when anyone is failing to lose weight while on the ketogenic diet, it's due to not achieving ketosis.

The most common cause that some people do not go into the state of ketosis is forgetting to reduce on the amount of carbs. According to an article on the keto diet, carbohydrates should not exceed 10% of an individual's calorie consumption.

More specifically, many keto diets require you to limit between 20 and 50 grams of carbohydrates daily.

At times, you might feel as if you have already hugely cut down on your carb intake. But, in reality, you might yet be consuming enough carbs for your body to make energy from glucose, which in turn will hinder the body from effectively burning fat. 

Anyone who isn't losing weight while on the ketogenic diet might benefit from buying a home testing kit. Such kits provide test strips which check for the existence of ketones in your urine. A positive outcome is a good indication that your body is now in ketosis.

Another option: use a little machine known as a ketone breath analyzer which locates ketones in your breath.

Home testing could be a great way for anyone to make sure that they in fact are achieving ketosis. You can utilize this critical information to adjust your diet to help you reach that weight loss goal.

2.  Consuming too much protein

Several low carb diets permit a modest amount of protein. Some individuals assume that a low carb and high protein diet is a ketogenic diet. But this kind of diet is not likely to help result in ketosis since the body could break down extra proteins into amino acids and then turn them to kinds of sugar.

Anyone who's on the ketogenic diet will get the majority of calories from fat, which ought to represent around 55 to 60% of calorie intake. This fat intake provides little space for protein. If protein comprises over 35% of your diet, it's most unlikely you'll go into ketosis.

3.  Consuming excess acceptable carbs

On the ketogenic diet, many kinds of carbohydrate are acceptable like dairy and nuts. Since these foods are generally high fat and nutrient dense foods, they make a fine addition to your keto diet. But they have carbs, too.

And eating too much of such foods will prevent you from reaching and maintaining ketosis.

4.  Eating maltitol

Sugar alcohols are usually a fine option for those following the keto diet.  Although they provide sweetness without boosting net carbs in your body, not all sugar alcohols are the same.

Maltitol happens to be a sugar alcohol that's not keto-friendly. Despite maltitol being a low glycemic index sugar, it yet impacts blood sugar levels. And this effect is sufficient to hinder an individual from experiencing ketosis.

5.  Not counting calories

Anyone who consumes more calories than his body could burn is rather less likely to see weight loss. In fact, people who commonly consume excessive calories might put on weight, though they are already in ketosis.

High fat foods usually contain several additional calories than foods which are high in proteins and carbs. It's thus, vital that you monitor the number of calories which you eat daily.

Following a balanced diet plan could help you work toward achieving your target weight.

6.  Habit of snacking

Although an individual has a great meal plan to initiate, if he can't quit the habit of snacking constantly, this could largely boost the calorie intake. A snack might help stop hunger pangs, but it also could quickly harm the weight loss outcome.

7.  Drinking alcohol

Several alcoholic beverages such as beer and wine are high in carbs. The majority types of ketogenic diet don't permit these kinds of alcohol.

Hard alcohols, like vodka and gin, contain less carbohydrates, which means they are typically acceptable on a ketogenic diet. However, these drinks tend to be quite calorie dense and as such these options could prevent weight loss.

Either reduce or eliminate your intake of alcohol, for it too easily increases calorie intake and provides no nutrients to your body.

8.  Some or no exercise

Exercise is a significant factor in helping you to stay healthy. Also, exercise stimulates your body's metabolism as well as burn calories. Thus, it's a remarkable tool for dieters.

Exercise could play an even more important role while on a keto diet, for the high fat foods which anyone consumes contain several calories. Burning calories via exercise could help you get to your desired weight.

9.  High stress

A lifestyle full of high stress also could prevent anyone from shedding weight on the ketogenic diet. According to a 2012 study, stress could bring about changes in hormone levels, which in turn could result in either problems losing weight or weight gain.

Chronic stress might in addition cause a person to desire comfort foods, which only add more calories to the current diet.

10.  Underlying medical conditions

At times, anyone might be doing everything correctly and yet not succeed in losing weight while on the keto diet. In certain cases, this might be happening because of an underlying condition which is causing weight gain or hindering weight loss. Or a medicine that another person is currently taking to treat the underlying condition might turn out to be causing greater appetite as a negative side effect.

Conditions which could lead to weight gain range from polycystic ovary syndrome, high insulin levels, hypothyroidism, Cushing's syndrome to depression.

You are advised to see your doctor if unable to experience weight loss while following a strict keto diet and exercise plan. Your doctor might order tests to figure out what is hindering weight loss. By addressing the underlying condition might resolve the issue.

New Study Proves Amino Acids Suppress Appetite